Buffalo was initially installed as just a 3.5-point favorite and actually saw a dip to 3 points shortly thereafter. Following Week 5 outcomes, however, which included a very high-profile nationally televised road win for the Bills over the Chiefs – the number began to shoot up. It steadily climbed until getting as high as 6 points before dipping down slightly to 5.5 going into the weekend. It is now Buffalo -6.

Meanwhile, the total opened at 53.5 points, a figure the public quickly bet up to 54 early in the week. The number has since toggled between 53 and 54 – with some stops at 53.5 – over the subsequent days. It is currently set at 53.5 points. The combination of the Bills’ powerful offense, which was on prominent display in the aforementioned shootout win over KC, and the Titans’ questionable defense certainly seems to be the driving force behind keeping this number plump.

 Buffalo boasts a massive 21-point average net margin of victory, along with a net +/- of 15.0 points ATS. In contrast, the Titans carry 0.4 and -1.8 figures in those respective categories.

Additionally, the Titans are allowing 377.4 total yards and 26.0 points per game, while the Allen-led Bills attack is tops in the NFL with 34.4 points per contest and averages 410.4 total yards per game. Buffalo has also impressively scored TDs on 85.7 percent of its red zone trips on the road, and although the Bills defense figures to make life difficult on Tennessee. The Titans are averaging 26.4 points per game and will have Julio Jones back for this contest.

• The Bills are 4-1 (80.0 percent) against the spread this season, including 2-0 as a road team and 3-1 in conference games. The Over is 2-3 in Buffalo’s games this season, including 1-1 in its away contests and 1-3 in its conference games.
• The Titans are 3-2 (60.0 percent) against the spread this season, including 1-1 as a home team and 2-1 (66.7 percent) in AFC matchups. The Over is 3-2 (60.0 percent) in Tennessee’s games this season, including 0-2 in its home games and 2-1 (66.7 percent) in its games against conference opponents.