Pick: Kansas City 27, Los Angeles 24
Jacoby Brissett and Joe Flacco. After you call the police on this game, sit down and expect a defensive struggle with a ton of running. That favors the team with Nick Chubb and Kareem Hunt.
Pick: Cleveland 20, New York 17
If Washington wins, perhaps the Commanders are more of a threat in the NFC East than previously believed. However, the Lions are playing to keep hope going after a tough Week 1 loss.
Pick: Detroit 24, Washington 23
Excellent divisional clash, and the Bucs are trying to win their first regular-season game over the Saints in the Tom Brady era. The big issue for Tampa Bay? Injuries galore.
Pick: New Orleans 27, Tampa Bay 24
Love the fight we saw from the Giants in Nashville, earning a last-second win. Carolina is more talented, but New York looks unified under first-year head coach Brian Daboll.
Pick: New York 22, Carolina 18
Offensive football is about to be set back to 1938. Pittsburgh and New England are both hoping to play defense, win situational battles, get a few turnovers and capitalize when they come.
Pick: Pittsburgh 17, New England 16
The Colts have to win this game. They can’t come out of tilts against the Texans and Jaguars without a victory. Meanwhile, if Jacksonville goes 0-2, it feels like more of the same for this downtrodden franchise.
Pick: Indianapolis 25, Jacksonville 23
The Ravens and Dolphins both looked good in Week 1. Baltimore is the more complete team, at home. Tua Tagovailoa will need to have a great game to crack the Ravens’ defense.
Pick: Baltimore 24, Miami 20
If the Rams struggle here, it’s a huge red flag. Atlanta played New Orleans tough on Sunday, but it shouldn’t be a match for a Los Angeles team on a long break.
Pick: Los Angeles 31, Atlanta 24
Can Geno Smith outplay Trey Lance? It feels like Seattle had some magic on Monday night, but the Seahawks will bring confidence to the west coast. Expect a tough game.
Pick: San Francisco 21, Seattle 16
Cooper Rush isn’t beating Joe Burrow. If he does, Cincinnati has major problems.
Pick: Cincinnati 23, Dallas 14
Let’s ride? The Broncos were underwhelming — to be kind — against the Seahawks on Monday. Now a home opener against another lackluster opponent. Expect Denver to bounce back.
Pick: Denver 30, Houston 17
The offenses should both score plenty, but the Raiders are a better team, at home, with Derek Carr attempting to bounce back after three interceptions against the Chargers.
Pick: Las Vegas 33, Arizona 28
This should be where the Packers show their mettle, handle the overwhelmed Bears and run away with a victory at home. That doesn’t happen, Green Bay has serious issues.
Pick: Green Bay 27, Chicago 17
Tough to see a path for the Titans here. Tennessee can’t match up with Buffalo on either side of the ball. Josh Allen could have another monster day in primetime.
Pick: Buffalo 31, Tennessee 14
Terrific contest to end the week. Whoever wins is going to be seen as a legit contender in the NFC. Philadelphia and Minnesota are very evenly matched, so take the home squad.
Pick: Philadelphia 27, Minnesota 24