San Francisco 49ers (+650)
The Niners continue to roll with Brock Purdy under center distributing to a wealth of offensive weapons.
Kansas City Chiefs (+700)
Travis Kelce (knee) returned and Chris Jones ended his holdout this week before helping the Chiefs earn a win in Jacksonville. The rest of the AFC West is off to a rough start, so the Chiefs look likely to earn an eighth straight division title.
Philadelphia Eagles (+750)
The Eagles have been able to ride their running game to a 2-0 start, but their odds have slightly lengthened with the Cowboys looking like a prime contender in the NFC East.
Dallas Cowboys (+750)
Micah Parsons keys what might be the best defense in the NFL and Dak Prescott has looked comfortable in two blowout wins with Mike McCarthy calling the plays.
Buffalo Bills (+1000)
Josh Allen bounced back along with the rest of the Bills in a blowout win over the Raiders at Ralph Wilson Stadium.
Miami Dolphins (+1300)
The Dolphins (+105) are slightly ahead of the Bills (+110) in terms of odds to win the AFC East. Miami’s offense has looked unstoppable when Tua Tagovailoa is healthy.
Baltimore Ravens (+1400)
Despite dealing with a long list of injuries through two weeks, the Ravens have pulled out a pair of wins. Lamar Jackson should only grow more comfortable with a new offensive system as the season progresses.
Cleveland Browns (+1800)
After opening with a dominant defensive performance against the Bengals, the Browns look to provide an encore in Pittsburgh on Monday night.
Cincinnati Bengals (+1800)
The Bengals have started slowly again and Joe Burrow appeared to have aggravated his calf injury during another division loss to the Ravens.
Detroit Lions (+2000)
The Lions experienced a letdown after opening with a win in Kansas City. They’re still favored to win the downtrodden NFC North.
Jacksonville Jaguars (+2500)
The Jaguars have dropped from around -500 to -120 odds at FanDuel to win the AFC South after falling short against the Chiefs while the Titans pulled out an overtime win.
Los Angeles Chargers (+3000)
The Chargers have lost four straight one-score games going back to last year, an eyebrow-raising trend that puts Brandon Staley on the hot seat early in the season.
New Orleans Saints (+3500)
Derek Carr can provide some stability for the Saints offense, which could be an explosive unit if Michael Thomas stays healthy and Alvin Kamara (suspension) returns strong.
Atlanta Falcons (+4000)
Arthur Smith took some chances in Week 2 against the Packers, with second-year quarterback Desmond Ridder showing some growth in the comeback.
Seattle Seahawks (+4000)
The Seahawks offense bounced back after a dreadful second half against the Rams. Their injury-riddled defense still coughed up 400-plus yards in a narrow win at Detroit.
Green Bay Packers (+5000)
Jordan Love has executed well in Matt LaFleur’s system, but the Packers appear to be a couple years away from contending with a young quarterback.
Los Angeles Rams (+7000)
The Rams have impressed in their first two games against division foes and Cooper Kupp (hamstring) might be able to return by Week 5.
Minnesota Vikings (+7000)
Despite their disappointing 0-2 start, the Vikings (+500) are still alive to repeat as NFC North champions with all of their division games still to come.
New York Jets (+7000)
Aaron Rodgers (Achilles) claims that he will rehab quickly enough to potentially return for the playoffs, yet the Jets will have to win quite a few games with Zach Wilson to stay competitive in the brutal AFC East.
New England Patriots (+7000)
New England’s futures have shortened in part because of the Jets’ injury woes. The Patriots have started 0-2 for the first time since 2001.
Denver Broncos (+7000)
Sean Payton devised a good game plan that had the Broncos up big in Week 2 before they squandered that lead in the second half.
Tampa Bay Buccaneers (+7000)
Baker Mayfield has played turnover-free football and the Bucs defense has brought home two close wins to open their season.
Pittsburgh Steelers (+7500)
The Steelers came into the season with some preseason hype that immediately evaporated when the 49ers demolished them in their home opener.
Tennessee Titans (+7500)
Mike Vrabel steered his squad to an overtime win at home as the Titans continue to work around a struggling offensive line.
New York Giants (+7500)
The Giants looked like the worst team in the NFL for six quarters before pulling out a miraculous comeback in Arizona. Saquon Barkley (ankle) got hurt in the win.
Washington Commanders (+7500)
The youth movement has begun in Washington with Sam Howell, Jahan Dotson, and rookie Emmanuel Forbes Jr. making impact plays in a comeback win at Denver.
Las Vegas Raiders (+10000)
Both Davante Adams and Jakobi Meyers are in concussion protocol, leaving the Raiders without much talent at the skill positions.
Indianapolis Colts (+13000)
Early returns from Anthony Richardson have been great, although the fourth overall pick has put his body on the line enough to get knocked out of two games with injury.
Carolina Panthers (+15000)
Bryce Young is learning on the job and the Panthers don’t have many veterans around the top overall pick.
Chicago Bears (+15000)
Justin Fields is regressing as a pocket passer early in his third season. The Bears defense is among the worst units in the NFL.
Houston Texans (+40000)
Demeco Ryans hasn’t had much success shoring up Houston’s leaky run defense, but C.J. Stroud has shown some promise while targeting his young receivers.
Arizona Cardinals (+40000)
The Cardinals have put up impressive fights in their first two losses of the season. Perhaps that level of effort opens the door for Kyler Murray (ACL) to return in a few weeks.